Goldman Sachs CEO David Solomon cautioned Tuesday that the U.S. economy might be headed for a downturn that could make investing and business decisions more difficult.

"I think it's a time to be cautious, and I think that if you're running a risk-based business, it's a time to think more cautiously about your risk box, your risk appetite," Solomon said during a live interview on CNBC's "Squawk Box."

"I think you have to expect that there's more volatility on the horizon now. That doesn';t mean for sure that we have a really difficult economic scenario. But on the distribution of outcomes, there's a good chance that we have a recession in the United States," he added.

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